Diagnostic Products for Infection Imaging
Lyophilised DiagnobactTM kit
DRDO has produced a number of
radiopharmaceutical kits for infection/inflammation imaging that are used
regularly for diagnostic purposes. These include Tc-99m citrate, Tc-99m dextran
and Tc-99m polyclonal human immunoglobin. Many specific bacterial infection
imaging agents have also been developed that are useful in detection of site of
bacterial infection in human body upon reconstitution with Tc-99m. These include
fluoroquinalone antibiotics like ciprofloxacin, norfloxacin, sparfloxacin,
gaityfloxacin and other like clamindamycin. Tc-99m ciprofloxacin (DiagnobactTM)
kit has been approved for marketing after completing successful multicentric
trial in more than 500 cases in 26 nuclear medicine centres across the country.
Its primary use is in diagnosis of infection in painful prosthesis, fever of
unknown origin and differentiation of infective lesion from simple inflammation.
It is also useful for diagnosis and follow up of tubercular osteomyelitis.
Scintigraphy with Tc-99m ethambutol shows four active TB sites including two unsuspected ones
Osteoarthritis of knee and
active ulcerative colitis have been identified by DRDO as pharmacoscintigraphy
human models for development of novel antiinflammatory drugs. Using
radiopharmaceuticals like Tc-99m dextran, HES or HIG, inflammation in the lesion
is quantified. Reduction, if any, in the inflammation caused by administration
of a novel drug or a drug-delivery system is then compared to a standard drug
like aspirin to confirm efficacy of the new drug.